Future Potential of Stem Cells Conditioned Medium (Secretome) in Osteoarthritis

Osteoarthritis (OA) is a leading cause of disability worldwide, particularly among the elderly, and is characterized by progressive cartilage degeneration. Despite various therapeutic options, no treatment currently exists to reverse cartilage damage. This systematic review aims to evaluate the potential of mesenchymal stem cell (MSC) secretomes as a novel therapeutic approach for OA. MSCs are known for their regenerative and immune-modulating properties, and their secretomes, which include bioactive molecules like growth factors and cytokines, have shown promise in promoting cartilage repair and reducing inflammation. The review synthesizes findings from clinical trials and studies that explore the efficacy of MSC secretomes in OA treatment. The studies' results indicate that MSC secretomes can improve clinical outcomes, enhance cartilage regeneration, and provide long-term pain relief with minimal side effects. However, the studies also highlight the need for further research, particularly large-scale, multi-center trials, to standardize protocols and assess long-term outcomes. This review underscores the potential of MSC secretomes as a safe and effective alternative or adjunct to conventional OA therapies, offering new insights into regenerative medicine for OA management.